## Abstract In 1973 we reported the beneficial effects of azathioprine in a double blind, crossβover study in 17 patients with classic rheumatoid arthritis. During subsequent followβup over a mean period of 40 months, 4 patients had discontinued therapy because of poor therapeutic response and 1 be
Methotrexate versus azathioprine in rheumatoid arthritis
β Scribed by Jeurissen, M. E. C.
- Publisher
- Springer
- Year
- 1994
- Tongue
- Dutch
- Weight
- 482 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1573-739X
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Methotrexate (MTX) is effective in the treatment of refractory rheumatoid arthritis (RA). Its use by practitioners has become commonplace, even though it is not yet approved by the Food and Drug Administration for this use. One might assume, therefore, that there is a general understanding, among pr
Children with juvenile rheumatoid arthritis (JRA) have been reported to require higher doses (per kg body weight) of methotrexate (MTX) than adults with rheumatoid arthritis to control their disease. The purpose of the present study was to characterise the plasma pharmacokinetics of MTX and its majo