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Methotrexate therapy and liver fibrosis: are human prolyl hydroxylase and type IV collagen reliable and sensitive markers?

✍ Scribed by G. Tamaro; G. M. Danek; M. A. Mangiarotti; P. Tamaro; G. A. Zanazzo


Book ID
110573439
Publisher
Springer
Year
1995
Tongue
English
Weight
102 KB
Volume
25
Category
Article
ISSN
0940-5437

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Liver fibrosis was induced in rats both with carbon tetrachloride and dimethylnitrosamine. Assays were performed on steady-state levels of messenger RNAs in the liver for several collagens and basement membrane components. The results indicated marked increases in the steady-state levels of messenge