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Methotrexate loaded poly(l-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint

โœ Scribed by Linda S. Liang; John Jackson; Weixian Min; Verica Risovic; Kishor M. Wasan; Helen M. Burt

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
311 KB
Volume
93
Category
Article
ISSN
0022-3549

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Pharmacokinetic study of methotrexate fo
Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits
โœ Linda S. Liang; Wesley Wong; Helen M. Burt ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 387 KB

The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated following intra-articular injection of either MTX solution or controlled release MTX loaded microspheres in healthy rabbit joints. MTX solution or MTX loaded microspheres (size 30-100 mm) (10 mg MTX) was injected in