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Methotrexate in rheumatoid arthritis

✍ Scribed by Weinblatt, Michael E.; Kremer, Joel M.

Book ID
122917783
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
301 KB
Volume
19
Category
Article
ISSN
1097-6787

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Methotrexate (MTX) is effective in the treatment of refractory rheumatoid arthritis (RA). Its use by practitioners has become commonplace, even though it is not yet approved by the Food and Drug Administration for this use. One might assume, therefore, that there is a general understanding, among pr

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Children with juvenile rheumatoid arthritis (JRA) have been reported to require higher doses (per kg body weight) of methotrexate (MTX) than adults with rheumatoid arthritis to control their disease. The purpose of the present study was to characterise the plasma pharmacokinetics of MTX and its majo