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Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity

✍ Scribed by Robert BM Landewe; Ben EEM van den Borne; Ferdinand C Breedveld; Ben AC Dijkmans

Book ID: 117275475
Publisher: The Lancet
Year: 2000
Tongue: English
Weight: 64 KB
Volume: 355
Category: Article
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(00)02222-4

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## Abstract ## Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate (MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the pharmacokinetics of MTXGlu~1–5~ is required for optimal timing of blood sampling. The aim of this study w