## Abstract Nonenzymatic glycosylation or glycation of amino groups in peptides and proteins by D‐glucose is a universal reaction with important implications for the pathogenesis of many diseases including diabetes mellitus. Here a general approach is reported to synthesize site specifically glucos
Methods of the site-selective solid phase synthesis of peptide-derived Amadori products
✍ Scribed by Piotr Stefanowicz; Monika Kijewska; Katarzyna Kapczyńska; Zbigniew Szewczuk
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 326 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0939-4451
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📜 SIMILAR VOLUMES
## Abstract Glycation of peptides and proteins is a slow chemical reaction of reducing sugars modifying the amino groups. The first intermediates of this nonenzymatic glycosylation are the Amadori products that can undergo further chemical reactions, finally leading to advanced glycation end produc
## Abstract Gas phase fragmentation of peptide‐derived Amadori products was investigated using synthetic compounds regioselectively deuterated as well as labeled with ^18^O at aminofructose moiety. The eliminated molecule CH~2~O contains exclusively protons attached to carbon C6 of the aminofructos
## Abstract The electron capture dissociation (ECD) of peptide‐derived Amadori products has been successfully applied for their sequencing. In contrast to the collision induced dissociation (CID), based on the vibrational excitation of peptides, the ECD method does not produce ions formed by fragme
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.