[Methods in Molecular Biology] Hematological Malignancies Volume 999 || Detection of Clonal T-Cell Receptor Beta and Gamma Chain Gene Rearrangement by Polymerase Chain Reaction and Capillary Gel Electrophoresis
โ Scribed by Czader, Magdalena
- Book ID
- 120333476
- Publisher
- Humana Press
- Year
- 2013
- Weight
- 906 KB
- Category
- Article
- ISBN
- 1627033572
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A clonal-specific polymerase chain reaction technique to detect T-cell receptor delta gene rearrangement in acute lymphoblastic leukaemia (ALL) and non-Hodgkin's lymphoma (NHL) was evaluated. It was applied to detect minimal residual disease. A sensitive and specific technique to detect minimal resi
It has been recognized that clonal T-cell receptor delta (TCRG) gene rearrangement is present in both Tand B-cell malignancies. The highly sensitive polymerase chain reaction (PCR) technique may be applicable to cases of leukemia and lymphoma of non-T-cell origin for detection of minimal residual di