[Methods in Enzymology] Protein Phosphorylation Part B: Analysis of Protein Phosphorylation, Protein Kinase Inhibitors, and Protein Phosphatases Volume 201 || [40] Use of okadaic acid to inhibit protein phosphatases in intact cells
β Scribed by Hardie, D.Grahame
- Book ID
- 118146803
- Publisher
- Elsevier
- Year
- 1991
- Tongue
- English
- Weight
- 434 KB
- Category
- Article
- ISBN
- 0121821021
- ISSN
- 0076-6879
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π SIMILAR VOLUMES
Pt. A. Protein Kinases, Assays, Purification, Antibodies, Functional Analysis, Cloning, And Expression -- Pt. B. Analysis Of Protein Phosphorylation, Protein Kinase Inhibitors, And Protein Phosphates. Edited By Tony Hunter, Bartholomew M. Sefton. Includes Bibliographical References And Indexes.
In this study we show that multidrug-resistant (MDR) human KB-VI cells are highly resistant to the cytotoxicity of okadaic acid and calyculin A, 2 toxins from marine sponges that are potent inhibitors of type-I and type-2A protein phosphatases (PPl and PP2A). Cytotoxicity and colony-forming assays i