โ Scribed by J. K. Aronson (auth.), Norbert Rietbrock, Barry G. Woodcock, Gรผnter Neuhaus (eds.)
No coin nor oath required. For personal study only.
Front Matter....Pages II-11
Methods, clinical pharrnacology and the clinical pharmacologist....Pages 13-16
Techniques for studying the pharmacodynamic effects of cardiac glycosides on patientsโ own tissues during glycoside therapy....Pages 17-25
Methods for measuring changes in alertness induced by drugs and associated effects on human performance....Pages 26-36
Colour vision deficiencies in patients under long term-treatment with digitalis as detected by an Automated Farnsworthโs Munsell 100 Hue-Test....Pages 37-43
Pharmacodynamics and pharmacokinetics of a new aryl-alkylamine with negative chronotropic effects in man....Pages 44-45
The parotid gland as an โisolated organโ in vivo โOrgan-specific determination of ฮฒ -adrenergic stimulation in man....Pages 46-49
Correlation of pharmacodynamic activity and pharmacokinetics of Molsidomine....Pages 50-54
Evaluation of long-acting diuretics; investigations on tizolemide, a new diuretic: Part 1 Methodological approach....Pages 55-62
Pharmacokinetics of cyclophosphamide (Endoxan): The balance of cyclophosphamide metabolites in the mouse....Pages 63-67
Measurement of activity of immunosuppresive drugs in vitro ....Pages 68-69
Simultaneous modelling of pharmacokinetics and pharmacodynamics....Pages 70-78
Volume terms in pharmacokinetics....Pages 79-84
A method for in vivo-in vitro correlation using the additivity of Mean Times in biopharmaceutical models....Pages 85-93
The mean-transit-time as an aid in the development of galenical dosage forms....Pages 94-99
Two different methods for calculating constants describing verapamil pharmacokinetics in man....Pages 100-105
Cardiac glycosides in atrial fibrillation....Pages 106-113
Individual pharmacokinetic parameters in patients on long-term treatment....Pages 114-125
Aminoglycoside antibiotics: problems and methods....Pages 126-131
Preliminary observations of the pharmacokinetics of oral prednisolone....Pages 132-135
The statistical basis for forecasting individual pharmacokinetics....Pages 136-139
Prospective versus retrospective studies on the variance of digoxin plasma levels....Pages 140-146
Techniques for evaluating the steady-state serum concentrationโDose relationship in phenytoin Therapy....Pages 147-153
Drug monitoring in a clinical pharmacy laboratory: methods and case discussions....Pages 154-166
Drug utilisation and single and multiple dose pharmacokinetic and pharmacodynamic studies in assessing the influence of old age on drug action....Pages 167-168
Liver function tests and elimination of drugs in man....Pages 169-175
Urinary metabolite profile of antipyrine as a tool in the assessment of oxidative drug metabolizing capacity of man....Pages 176-186
Elimination of drug metabolites in liver disease....Pages 187-194
Theophylline plasma pharmacokinetics and urinary metabolite pattern in patients with liver diseases....Pages 195-202
First pass pharmacokinetics of methohexital in experimental liver disease of the rat....Pages 203-210
Can lignocaine kinetics be predicted?....Pages 211-217
Evaluation of the clinical significance of the first-pass effect of verapamil in patients....Pages 218-228
Evaluation of altered pharmacokinetics in intensive-care patients....Pages 229-241
The role of patient selection and patient description in clinical pharmacological studies....Pages 242-249
Role of volunteer selection in human pharmacology studies....Pages 250-263
Comparative pharmacokinetics of furosemide in animals and man....Pages 264-266
Methods for the measurement of drug binding to plasma proteins....Pages 267-273
Analytical reliability of methods to determine theophylline in serum or plasma....Pages 274-278
Evaluation of clonidine plasma levels in man using a highly sensitive radioimmunoassay....Pages 279-286
Simultaneous determination of pyrimidines, purines, azapurines and their metabolites in man by HPLC....Pages 287-295
Quantitative thin-layer chromatography of diuretics in clinical pharmacology....Pages 296-301
Evaluation of positive inotropic and chronotropic activity exhibited by extracts from human kidneys....Pages 302-309
Conjugated and free catecholamines in blood plasma....Pages 310-313
Pharmacological approach to the patient with pheochromocytoma....Pages 314-322
Beidellite (an aluminium silicate) and digoxin, checking of a suspected drug interaction by in vivo and in vitro assays....Pages 323-328
In situ measurement of left ventricular pressure and cardiac output in rat heart after acute and chronic Adriamycin application....Pages 329-333
Excretion profiles of L-alanine-aminopeptidase in normal subjects; a method for the evaluation of nephrotoxicity in man....Pages 334-339
Influence of hydrochlorothiazide on uric acid excretion in normal subjects....Pages 340-345
Back Matter....Pages 346-351
Pharmacology/Toxicology; Pharmacy; Medicine/Public Health, general
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