Methods for the determination of neutral drugs as well as betablockers and β2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS

✍ Scribed by T. A. Ternes; Roman Hirsch; Jutta Mueller; Klaus Haberer

• Publisher: Springer
• Year: 1998
• Tongue: English
• Weight: 287 KB
• Volume: 362
• Category: Article
• ISSN: 1618-2650
• DOI: 10.1007/s002160051083

✦ Synopsis

An analytical method has been developed which allows the determination of 22 different neutral and weakly basic drugs belonging to several different medicinal classes like antiphlogistics, betablockers, β 2 -sympathomimetics, lipid regulators, antiepileptic agents, psychiatric drugs and vasodilators in waste water as well as in river and drinking water. A method including solid phase extraction, derivatization by silylation and detection by GC/MS permits detection down to 5 ng/L. The recovery rates mostly exceeded 70%. However, the determination of phenazone, carbamazepine, cyclophosphamide, ifosfamide and pentoxiphylline is frequently disturbed by organic co-extractants in real samples of rivers and waste waters. Therefore, a time saving alternative method has been developed, combining solid phase extraction (as an enrichment step) together with detection by LC-electrospray/MS/MS allowing the measurement of 5 neutral drugs. Detection limits down to 10 ng/L have been achieved even for organically highly contaminated waters like sewage treatment plant effluents.