[Methods and Principles in Medicinal Chemistry] Drug Metabolism Prediction || Predicting Toxic Effects of Metabolites

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Drug Metabolism Prediction || Metabolite Detection and Profiling

✍ Kirchmair, Johannes 📂 Article 📅 2014 🏛 Wiley ⚖ 322 KB

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Hit and Lead Profiling Volume 43 || Drug Metabolism and Reactive Metabolites

✍ Faller, Bernard; Urban, Laszlo 📂 Article 📅 2009 🏛 Wiley 🌐 German ⚖ 164 KB

The enormous cost incurred when a candidate drug fails in a clinical trial because of poor pharmacological parameters or severe side effects makes it imperative to screen for "safe" drugs in the very early stages of drug development. Various biochemical and other in vitro assays are thus used in con

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Drug Metabolism Prediction || In Vitro Models for Metabolism: Applicability for Research on Food Bioactives

✍ Kirchmair, Johannes 📂 Article 📅 2014 🏛 Wiley ⚖ 276 KB

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability Volume 40 || In Silico Prediction of Solubility

✍ van de Waterbeemd, Han; Testa, Bernard 📂 Article 📅 2008 🏛 Wiley ⚖ 161 KB

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Prodrugs and Targeted Delivery (Towards Better ADME Properties) || Reducing Presystemic Drug Metabolism

✍ Rautio, Jarkko 📂 Article 📅 2011 🏛 Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German ⚖ 292 KB

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Hit and Lead Profiling Volume 43 || Membrane Permeability- Measurement and Prediction in Drug Discovery

✍ Faller, Bernard; Urban, Laszlo 📂 Article 📅 2009 🏛 Wiley 🌐 German ⚖ 310 KB

The enormous cost incurred when a candidate drug fails in a clinical trial because of poor pharmacological parameters or severe side effects makes it imperative to screen for "safe" drugs in the very early stages of drug development. Various biochemical and other in vitro assays are thus used in con