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Methods and mechanisms for the development of MTX resistance in human lymphoid cells

✍ Scribed by A. Alam; A. J. Geddes; A. C. T. North

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
583 KB
Volume
31
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Conditions are described for the development of methotrexate resistance in CCRF/CEM human lymphoid cells and an attempt is made to distinguish between those conditions that lead to methotrexate resistance through impairment of cellular transport of methotrexate and those that lead to resistance through enhanced production of dihydrofolate reductase. A restistant line showing a 200‐fold enhancement of dihydrofolate reductase has been obtained. The CCRF/CEM human cells are much more sensitive to methotrexate than are murine cells.

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