Methodological considerations in studying natural history of HBeAg-negative and -positive chronic hepatitis B
β Scribed by Guohong Cai; Wen Yin
- Book ID
- 115293878
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 86 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0106-9543
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BACKGROUND: Available treatments for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B are associated with poor sustained responses. As a result, nucleoside and nucleotide analogues are typically continued indefinitely, a strategy associated with the risk of resistance and unknown long-term
## Abstract Hepatitis B e antigen (HBeAg)βnegative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7β30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia.