Methodological and statistical issues of quality of life (QoL) and economic evaluation in cancer clinical trials: report of a workshop
โ Scribed by N Neymark; W Kiebert; K Torfs; L Davies; P Fayers; B Hillner; R Gelber; G Guyatt; P Kind; D Machin; E Nord; D Osoba; D Revicki; K Schulman; K Simpson
- Book ID
- 117665799
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 154 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0959-8049
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We summarize issues that arise when considering quality of life (QOL) data in cancer clinical trials, especially those related to missing data. We describe different types of missing data mechanisms, and discuss ways of assessing and testing missing data mechanisms. A section on presentation of stud
Assessment of health related quality of life (QOL) has become an important endpoint in many clinical trials of cancer therapy. Most of these studies entail multiple QOL scales that are assessed repeatedly over time. As a result, the problem of multiple comparisons is a primary analytic challenge wit