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Method to determine in vivo the relaxation time T1 of hyperpolarized xenon in rat brain

✍ Scribed by Philippe Choquet; Jean-Noël Hyacinthe; Guillaume Duhamel; Emmanuelle Grillon; Jean-Louis Leviel; André Constantinesco; Anne Ziegler

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
130 KB
Volume
49
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The magnetic polarization of the stable ^129^Xe isotope may be enhanced dramatically by means of optical techniques and, in principle, hyperpolarized ^129^Xe MRI should allow quantitative mapping of cerebral blood flow with better spatial resolution than scintigraphic techniques. A parameter necessary for this quantitation, and not previously known, is the longitudinal relaxation time (T) of ^129^Xe in brain tissue in vivo: a method for determining this is reported. The time course of the MR signal in the brain during arterial injection of hyperpolarized ^129^Xe in a lipid emulsion was analyzed using an extended two‐compartment model. The model uses experimentally determined values of the RF flip angle and the T~1~ of ^129^Xe in the lipid emulsion. Measurements on rats, in vivo, at 2.35 T gave T = 3.6 ± 2.1 sec (±SD, n = 6). This method enables quantitative mapping of cerebral blood flow. Magn Reson Med 49:1014–1018, 2003. © 2003 Wiley‐Liss, Inc.

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