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Method for separating D-ribono-1,4-lactone and D-arabono-1,4-lactone

✍ Scribed by V. T. Novikov; E. V. Gromova; I. A. Avrutskaya; M. Ya. Fioshin


Book ID
112396552
Publisher
Springer
Year
1976
Tongue
English
Weight
136 KB
Volume
10
Category
Article
ISSN
0091-150X

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D-Ribono-1,4-lactone was treated with ethylamine in DMF to afford N-ethyl-D-ribonamide 9a in quantitative yield. Bromination of amide 9a by the system SOBr 2 in DMF or PPh 3 /CBr 4 in pyridine led, after acetylation, to epoxide 7. However, treatment of amide 9a with acetyl bromide in dioxane followe