Method for predicting solubilities of solids in mixed solvents

✍ Scribed by Martin E. Ellegaard; Jens Abildskov; John P. O'Connell

• Publisher: American Institute of Chemical Engineers
• Year: 2009
• Tongue: English
• Weight: 155 KB
• Volume: 55
• Category: Article
• ISSN: 0001-1541
• DOI: 10.1002/aic.11759

✦ Synopsis

Abstract

A method is presented for predicting solubilities of solid solutes in mixed solvents, based on excess Henry's law constants. The basis is statistical mechanical fluctuation solution theory for composition derivatives of solute/solvent infinite dilution activity coefficients. Suitable approximations are made for a single parameter characterizing solute/solvent interactions. Comparisons with available data show that the method is successful in describing a variety of observed mixed solvent solubility behavior, including nearly ideal systems with small excess solubilities, systems with solute‐independent excess solubilities, and systems deviating from these simple rules. Successful predictions for new solvent mixtures can be made using limited data from other mixtures. © 2009 American Institute of Chemical Engineers AIChE J, 2009