Methionine oxidation and aging
β Scribed by Earl R. Stadtman; Holly Van Remmen; Arlan Richardson; Nancy B. Wehr; Rodney L. Levine
- Book ID
- 103823267
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 169 KB
- Volume
- 1703
- Category
- Article
- ISSN
- 1570-9639
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The rnyeloperoxidase-mediated oxidation of methionine was studied using a purified canine myeloperoxidase preparation. The system required the simultaneous presence of myeloperoxidase, H202, and a halide anion. When 0.1 mM H 2 0 2 was used, the system has a pH optimum of approximately pH 5-5.5. Brom
The aggregation of normally soluble a-synuclein in the dopaminergic neurons of the substantia nigra is a crucial step in the pathogenesis of Parkinson's disease. Oxidative stress is believed to be a contributing factor in this disorder. Because it lacks Trp and Cys residues, mild oxidation of a-synu