Methionine adenosyltransferase and S-adenosylmethionine in the developing rat lens
β Scribed by Arthur M. Geller; Malak Y.S. Kotb; Howard M. Jernigan Jr; Nicholas M. Kredich
- Book ID
- 115893916
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 1003 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0014-4835
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Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Methionine adenosyltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor. SAMe metabolism generates two methylation inhibitors, methylthioadenosine (MTA) and S-adenos
We investigated the mechanism of nitric oxide (NO) action on hepatic methionine adenosyltransferase (MAT) activity using S-nitrosoglutathione (GSNO) as NO donor. Hepatic MAT plays an essential role in the metabolism of methionine, converting this amino acid into S-adenosylmethionine. Hepatic MAT exi
Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. Mature liver expresses mainly MAT1A. We showed a switch from MAT1A to MAT2A gene