Methaqualone–diphenhydramine interaction study in humans

✍ Scribed by K. W. Hindmarsh; S. M. Wallace; C. B. Schneider; E. D. Korchinski

• Book ID: 102917216
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 590 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720220

✦ Synopsis

Furthermore, the vaginal absorption of phenolsulfonphthalein after the consecutive administration resulted in an enhanced absorption with less variance, regardless of the initial stage of the estrous cycle (Fig. 4). The better absorption supports the halt of the cycle a t diestrus and possibly reveals the thinner epithelial membrane.

In long-term therapy with vaginal application of leuprolide, the reproductive cycle effects would be leveled off by continuous administration, either parenterally or vaginally, although some fluctuation in absorption may be unavoidable a t the initial period of administration. The authors' previous proposal of the vaginal application of leuprolide as a rational method for long-term anticancer therapy was supported by the findings of the present study.