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Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice

✍ Scribed by Zhao, Ran-ran; Xu, Xiao-chen; Xu, Fei; Zhang, Wei-li; Zhang, Wen-lin; Liu, Liang-min; Wang, Wei-ping


Book ID
122316781
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
607 KB
Volume
448
Category
Article
ISSN
0006-291X

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## Abstract The present study investigated whether infusion of brain‐derived neurotrophic factor (BDNF) could ameliorate stress‐induced impairments in spatial learning and memory as well as hippocampal long‐term potentiation (LTP) of rats. Chronic immobilization stress (2 h/day Γ— 7 days) significan