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Metastatic renal cell carcinoma to the orofacial region: A novel method to alleviate symptoms and control disease progression

✍ Scribed by Zaid Hamdoon; Waseem Jerjes; Tahwinder Upile; Sarah Akram; Colin Hopper


Book ID
119344396
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
776 KB
Volume
7
Category
Article
ISSN
1572-1000

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## Abstract ## BACKGROUND Renal cell carcinoma (RCC) is characterized by von Hippel‐Lindau gene inactivation and vascular endothelial growth factor (VEGF) overproduction. The mechanism of VEGF overproduction may involve protein kinase C (PKC) delta and zeta isoforms. UCN‐01 (7‐hydroxystaurosporine