Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

Downregulation of programmed cell death

Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

✍ Michiko Yasuda; Tobias Schmid; Daniela Rübsamen; Nancy H. Colburn; Kazuhiro Irie 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 385 KB

## Abstract Ample evidence has shown key roles of inflammation in tumor promotion and carcinogenesis, and tumor‐associated macrophages are known to promote tumor growth and dissemination. Programmed cell death 4 (Pdcd4) is a novel tumor suppressor, and although various studies have revealed that th