We report on two unrelated children, a girl and a boy, with regressive metaphyseal dysplasia. Both children had bow legs and a transient growth decline in early childhood. Metaphyseal modifications of the long bones in the children were most conspicuous at an early age and then subsided by age 2 to
Metaphysics of genetic architecture and computation
β Scribed by Karl Chu
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 974 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0003-8504
- DOI
- 10.1002/ad.292
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β¦ Synopsis
Abstract
Karl Chu ruminates on the farβreaching impact that the convergence of computation and biogenetics will have on the unfolding history of man and nature. Could the world be βmoving into the soβcalled PostβHuman Era, which will bring forth a new kind of biomachinic mutation of organic and inorganic substancesβ? How can architects reconfigure the practice of their discipline in order to meet the demands of this computational and biogenetic revolution? Copyright Β© 2006 John Wiley & Sons, Ltd.
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We describe two sibs with geroderma osteodysplasticum (GO) who, in addition to the known clinical and radiologic manifestations of the disorder, presented a metaphyseal peg indenting the epiphysis of the long bones, particularly at the knees. The peg was visible only at the age of 4 to 5 years but w