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Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease

✍ Scribed by Manuchair Ebadi; Holly Brown-Borg; Hesham El Refaey; Brij B. Singh; Scott Garrett; Shaik Shavali; Sushil K. Sharma

Book ID
116753200
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
220 KB
Volume
134
Category
Article
ISSN
0169-328X

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o