Metallothionein Gene Therapy for Chemical-Induced Liver Fibrosis in Mice
β Scribed by JIANG, Y; KANG, Y
- Book ID
- 125483783
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 786 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1525-0016
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Background Paracetamol overdose causes acute liver damage which leads to severe centrilobular hepatic necrosis. The hepatotoxic effect is caused by reactive metabolites and oxidative stress. Since extracellular superoxide dismutase (EC-SOD) protects tissues against the harmful effects of superoxide
Cadmium is a toxic metal that induces the expression of metallothionein genes in many tissues and that binds avidly to metallothionein, a soluble transition metal binding protein. The present study examined the temporal pattern and magnitude of accumulation of metallothionein mRNA in liver of C57BL