Metallkomplexe mit biologisch wichtigen Liganden, LVIII.C-Allylglycin- undC-Vinylglycin-Komplexe von Palladium(II), Platin(II), Rhodium(III), Iridium(III) und deren Reaktionen mit Nucleophilen

✍ Scribed by Zahn, Ingo ;Polborn, Kurt ;Wagner, Barbara ;Beck, Wolfgang

• Publisher: Wiley (John Wiley & Sons)
• Year: 1991
• Tongue: English
• Weight: 843 KB
• Volume: 124
• Category: Article
• ISSN: 0009-2940
• DOI: 10.1002/cber.19911240513

✦ Synopsis

Metal Complexes of Biologically Important Ligands, LVIII. – C‐Allylglycine and C‐Vinylglycine Complexes of Palladium(II), Platinum(II), Rhodium(III), Iridium(III) and Reactions with Nucleophiles

The synthesis of the complexes (R^1^~3~P)(Cl~2~Pt(C‐allylglycine ester) (1), (2) and of (η^5^‐C~5~Me~5~)Ir(C‐allylglycinate) (6) with tridentate O,N,η^2^;‐CC allylglycinate as ligand is described. Addition of enolates (Nu^−^) to the coordinated CC bond of 2 gives the γ‐C‐metallated α‐amino acid ester complexes (3). In most cases the platination occurs stereoselectively to yield the five‐membered metallacycle with the substitutents CH~2~Nu and CO~2~R^2^ in trans position. From 3d the new α‐amino acid H~2~NCH(CO~2~Me)‐(CH~2~)~3~C(Ph)(CO~2~Et)~21~ (4) is cleaved. The structures of 3c and 6 have been determined by X‐ray diffraction. C‐Vinylglycinate can be stabilized at the metal atom in the complexes (10) (MRh, Ir).