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Metallic nickel: A coupling reagent of benzyl halides and acyl halides to yield benzyl ketones

✍ Scribed by Shin-ichi Inaba; Reuben D. Rieke

Book ID
104217402
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
132 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis

Metallic nickel was found to be a convenient reductive coupling reagent for the preparation of benzyl ketones by the reaction of benzyl halides with acyl halides. The coupling reaction of acyl halides with organometallic reagents such as organomagnesium, zinc, cadmium,') and copper') compounds is an extremely useful tool for the synthesis of ketones. Recently, palladium-phosphine complexes have been employed as catalysts for the reaction with organozinc,3) tin,4) and mercury5) compounds utilizing easy oxidative addition of acyl halides to palladium.

Table I. Coupling reaction of benzyl halides with acyl halides mediated by metallic nickel Benzyl

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