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Metalation of 2-methyl-2(2-thienyl)-1, 3-dioxolane with n-butyllithium a new synthetic route to various 2,5-disubstituted thiophenes

โœ Scribed by Shelby F. Thames; Josef E. Mccleskey


Book ID
112121417
Publisher
Journal of Heterocyclic Chemistry
Year
1966
Tongue
English
Weight
252 KB
Volume
3
Category
Article
ISSN
0022-152X

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Abs&cC The two epimers of methyl 3-oxo-7-oxabicyclo[2.2.l]hept-S-en-2-carboxylate have been prepared from furan and methyl 3-bromopropiolate as a melhoxycarbonylketcne equivalent. The final step required hydrolysis of acetals by Nafion-H. 7-Oxabicyclo[2.2.l]hept-5-en-2-yl derivatives, in an opticall