Metalated epoxides as carbenoids. Stereospecific synthesis of functionalized spiro cyclopropanes via highly strained tricyclic intermediates

✍ Scribed by Claude Agami; Luc Dechoux; Eric Doris; Charles Mioskowski

• Book ID: 104257163
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 267 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00802-2

✦ Synopsis

Intmmoleculx cyclopropanation reaction of P,y-unsaturated epoxides yields highly strained tricyclo[4,1,0,0"5]heptane compounds whose hydrolysis affords a-keto Spiro cyclopropanes. Both steps of this one-pot reaction are stereospecitic.