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Metal-mediated asymmetric alkylation using chiral N-heterocyclic carbenes derived from chiral amines

✍ Scribed by Richard E. Douthwaite

Book ID
104010968
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
630 KB
Volume
251
Category
Article
ISSN
0010-8545

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✦ Synopsis

The significant advances in achiral catalysis using N-heterocyclic carbene (NHC) metal complexes have prompted intense investigation of chiral NHC derivatives for use in asymmetric catalysis in recent years. Discovery of new chiral NHC catalysts is supported by the development of synthetic routes to chiral NHC ligands and their metal complexes. Here routes to chiral NHC ligands derived principally from chiral diamines will be outlined and metal complex structures described in the context of application to asymmetric catalysis. Emphasis will be placed on palladium and copper catalysed asymmetric alkylations that serve to illustrate the potential and some limitations of NHC-based asymmetric catalysts.

πŸ“œ SIMILAR VOLUMES

[Topics in Organometallic Chemistry] N-H
[Topics in Organometallic Chemistry] N-Heterocyclic Carbenes in Transition Metal Catalysis Volume 21 || Chiral N-Heterocyclic Carbenes as Stereodirecting Ligands in Asymmetric Catalysis
✍ Glorius, Frank πŸ“‚ Article πŸ“… 2006 πŸ› Springer Berlin Heidelberg 🌐 German βš– 1001 KB

In This Book Leading Experts Have Surveyed Major Areas Of Application Of Nhc Metal Complexes In Catalysis. The Authors Have Placed A Special Focus On Nickel- And Palladium-catalyzed Reactions, On Applications In Metathesis Reactions, On Oxidation Reactions And On The Use Of Chiral Nhc-based Catalyst