Most cellular functions evaluated for biocompatibility are high-energy processes such as proliferation and therefore are not usually affected before a decrease in energy production is observed. Several studies have shown that metabolic functions are altered at much lower concentrations than several
✦ LIBER ✦
Metal ions in biological catalysis: from enzyme databases to general principles
✍ Scribed by Claudia Andreini; Ivano Bertini; Gabriele Cavallaro; Gemma L. Holliday; Janet M. Thornton
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 526 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1432-1327
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## Abstract A kinetic study of the nucleophilic substitution reaction of Y‐substituted phenyl diphenylphosphinothioates **2 a**–**g** with alkali‐metal ethoxides (MOEt; M=Li, Na, K) in anhydrous ethanol at (25.0±0.1) °C is reported. Plots of pseudo‐first‐order rate constants (__k__~obsd~) versus [M