✦ LIBER ✦

Metal-ion regulation of gene expression in yeast

✍ Scribed by Dennis R Winge; Laran T Jensen; Chandra Srinivasan

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 554 KB
Volume: 2
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(98)80063-x

No coin nor oath required. For personal study only.

✦ Synopsis

Metal-responsive transcription factors exist in yeast to modulate expression of genes that encode proteins involved in cellular uptake of copper, iron and zinc ions. These signal transduction pathways function in the cellular regulation of the intracellular concentration of free metal ions. A second component of metal homeostasis is the regulation of metal-ion binding through protein-mediated metallation. Copper-specific chaperones exist in yeast that route copper ions to the site of biosynthesis of copper-metalloenzymes.

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