Metal ion induced autoimmunity

✍ Scribed by Peter Griem; Ernst Gleichmann

• Book ID: 103973157
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 783 KB
• Volume: 7
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(95)80056-5

✦ Synopsis

Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechanism for activation of 'metal-specific' T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.