Metal ion binding by amino acids. The crystal structure of racemic magnesium bis(hydrogen aspartate) tetrahydrate Mg(L-AspH) (D-AspH) · 4 H2O
✍ Scribed by Schmidbaur, Hubert ;Bach, Ina ;Wilkinson, Dallas L. ;Müller, Gerhard
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1989
- Tongue
- English
- Weight
- 308 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0009-2940
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✦ Synopsis
Hydrogen m-aspartate complexes / Magnesium hydrogen DL-aspartate tetrahydrate / Hydrogen bonding Magnesium hydrogen L-aspartate hydrogen Baspartate tetrahydrate M~(D-As~H)(L-As~H) . 4 H20 crystallizes on cooling from the reaction mixture obtained from equivalent quantities of racemic aspartic acid and magnesium hydroxide in water under reflux conditions. The same product is also formed by slow racemization in analogous experiments carried out with pure as aspartic acid. -The compound crystallizes in the monoclinic space group P2,/c with centrosymmetric complex units, in which magnesium is in an octahedral environment of four water oxygen atoms in the equatorial plane and two f3-carboxylate oxygen atoms in axial positions. The NH: and cr-CO1 functions form a hydrogen-bonded system integrating the individual molecules into a three-dimensional network.
Magnesium complexes of the aminodicarboxylic acids are important pharmaceuticals with a wide spectrum of applications 'I. The two most important compositions are derived from L-aspartic acid L -A S ~H ~ with magnesium hydrogen L- aspartate chloride trihydrate2) Mg(L-AspH)Cl . 3 H 2 0 and magnesium bis(hydrogen L-aspartate) tetrahydrate') Mg(L-A S ~H ) ~