Metal contaminants in commercial preparations of nucleotides

✍ Scribed by Keith Tornheim; Thomas R. Gilbert; John M. Lowenstein

• Book ID: 102983207
• Publisher: Elsevier Science
• Year: 1980
• Tongue: English
• Weight: 586 KB
• Volume: 103
• Category: Article
• ISSN: 0003-2697
• DOI: 10.1016/0003-2697(80)90241-9

✦ Synopsis

Commercial preparations of ATP contain aluminum in amounts as high as 0.3 mol%. Aluminum ion causes a change in the spectrum of the dye Eriochrome Blue, and the effect is potentiated by adenine nucleotides. Hexokinase is inhibited by aluminum; the inhibition is antagonized by magnesium and is slowly relieved by EDTA. Some commercial preparations of ATP and ADP contain nearly 1 mol% of magnesium. A commercial preparation of GTP contains 0.07 mol% copper and 1.4 mol% barium.