Metal chelators change the human sperm motility pattern
β Scribed by Nicolai Wroblewski; Wolf-Bernhard Schill; Ralf Henkel
- Book ID
- 119420240
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 125 KB
- Volume
- 79
- Category
- Article
- ISSN
- 1556-5653
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## Abstract A variety of heavy metal chelating agents is known to prolong the fertilizing capacity and motility of sea urchin sperm. We report here that these agents maintain fertilizing capacity by preventing acrosome reactions which occur spontaneously after dilution of sperm into seawater. These
Limulus spermatozoa are nonmotile after dilution into sea water, and motility is initiated in situ by a sperm motility-initiating peptide (SMI) that emanates from Limulus eggs. In the absence of SMI, several structurally different chelators (EDTA, EGTA, phenanthroline, dipyridyl, cysteine, and dithi