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Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam

✍ Scribed by Justin S Bryans; Nicola E.A Chessum; Nathalie Huther; Andrew F Parsons; Franco Ghelfi

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 258 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)01030-5

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✦ Synopsis

The copper(I) or ruthenium(II)-mediated radical cyclisation of halo-amides has been utilised to afford functionalised pyrrolidinones via 5-endo-trig or 5-exo-trig radical cyclisation pathways. This methodology has been applied to novel and concise syntheses of the anti-epileptic drug gabapentin and the biologically active natural product pulchellalactam.

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