Metabotropic glutamate receptor activation modulates epileptiform activity in the hippocampus
β Scribed by P.A Rutecki; Y Yang
- Book ID
- 117492024
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 194 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0306-4522
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## Abstract Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G proteinβcoupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca^2+^ bin
Norepinephrine has been proposed to have both pro- and anticonvulsant properties. In the CA3 region of rat hippocampal slices, we studied the effects of norepinephrine and selective adrenergic agonists and antagonists on spontaneously occurring epileptiform discharges produced by either picrotoxin,