Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
β Scribed by Sergey Neyman; Denise Manahan-Vaughan
- Book ID
- 109027363
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 428 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0953-816X
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## Abstract In the hippocampal CA1 region, metabotropic glutamate subtype 1 (mGluR1) receptors have been implicated in a variety of physiological responses to glutamate, which include modulation of synaptic transmission and plasticity, as well as neuronal excitability and synchronization. The mGluR
Low frequency-induced short-term synaptic plasticity was investigated in hippocampal slices with 60-electrode recording array. Remarkably, the application of low-frequency stimulation (1 Hz) for a short duration (3-5 min) resulted in the induction of a slow-onset longterm potentiation (LTP) in the i