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Metabotropic glutamate autoreceptors of the mGlu5 subtype positively modulate neuronal glutamate release in the rat forebrain in vitro

✍ Scribed by Lisa S. Thomas; David E. Jane; John R. Harris; Martin J. Croucher


Book ID
117188465
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
471 KB
Volume
39
Category
Article
ISSN
0028-3908

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In non-synchronized, subconfluent secondary cultures of rat cortical astrocytes, the selective group-I metabotropic glutamate (mGlu) receptor agonist 3,5dihydroxyphenylglycine (DHPG) increased [methyl-3 H]-thymidine incorporation. This effect was mediated by the activation of the mGlu5 receptor, whi