Metabonomics studies of intact hepatic and renal cortical tissues from diabeticdb/dbmice using high-resolution magic-angle spinning1H NMR spectroscopy
โ Scribed by Jingjing Xu; Jun Zhang; Shuhui Cai; Jiyang Dong; James Y. Yang; Zhong Chen
- Book ID
- 105892201
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 451 KB
- Volume
- 393
- Category
- Article
- ISSN
- 1618-2650
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## Abstract Highโresolution magic angle spinning (HRMAS) ^1^H NMR spectroscopy is ideal for monitoring the metabolic environment within tissues, particularly when spectra are weighted by physical properties such as __T__~1~ and __T__~2~ relaxation times and apparent diffusion coefficients (ADCs). I
## Abstract The metabolic consequences of xenobioticโinduced toxicity were investigated using highโresolution magic angle spinning (MAS) NMR spectroscopy of intact tissue. Renal papillary necrosis (RPN) was induced in SpragueโDawley rats (n = 12) via a single i.p. dose of 250 mg/kg 2โbromoethanamin