Metabolites from the sponge plakortis simplex. II.: Isolation of four bioactive lactone compounds and of a novel related amino acid

✍ Scribed by Francesco Cafieri; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Massimo Di Rosa; Angela Ianaro

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 767 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00866-2

✦ Synopsis

Seven lactone metabolites, namely the known plakortones B-D (l-3). the novel plakwtones E (4) and F (5), and two novel Glactones, named simplactones A (6) and B ( ), have been isolated from the Caribbean sponge Plukortis simplex, and their structures characterized by spectroscopic and chemical means. In addition, the unprecedented amino acid 8 has been isolated from the same source. and a hypothesis of its biogenetic relationship with simplactones is herein reported. Plakortones B-F and compound 8 exhibited in vitro cytotoxic activity on WEHI 164, murine tibrosarcoma cell line.