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Metabolism of trichloroethene — in vivo and in vitro evidence for activation by glutathione conjugation

✍ Scribed by Wolfgang Dekant; Michael Koob; Dietrich Henschler


Book ID
113137371
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
659 KB
Volume
73
Category
Article
ISSN
0009-2797

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Mutagenicity of tetrachloroethene in the
✍ Vamvakas, Spyridon ;Herkenhoff, Martin ;Dekant, Wolfgang ;Henschler, Dietrich 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 649 KB

The mutagenicity of tetrachloroethene (tetra) and its S conjugate, S-(1,2,2-trichlorovinyl)glutathione (TCVG) was investigated using a modified Ames preincubation assay. TCVG was a potent mutagen in presence of rat kidney particulate fractions containing high concentrations of y-glutamyl transpeptid