Metabolism of toluene in man: gas-chromatographic determination of o-, m- and p-cresol in urine

✍ Scribed by Wolfgang Woiwode; Roman Wodarz; Klaus Drysch; Heinz Weichardt

• Publisher: Springer-Verlag
• Year: 1979
• Tongue: English
• Weight: 260 KB
• Volume: 43
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00333615

✦ Synopsis

Complete separation of phenol, o-, m- and p-cresol was achieved by capillary gas-chromatography. Urinary concentrations of cresols were determined quantitatively in samples from 10 male workers exposed to toluene. Besides p-cresol, o- and m-cresol were found to be urinary compounds in the case of the exposed group in contrast to normal persons. This finding was proved by gas-chromatography/mass spectrometry. The difference between both groups is significant. It is concluded that beside hippuric acid o-, m- and p-cresol are metabolites of toluene.