Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro
β Scribed by Roberts, John D.; Tong, William P.; Hartshorn, Jeanette N.; Hacker, Miles P.
- Book ID
- 122696545
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 333 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0304-3835
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## Abstract The IMP dehydrogenase inhibitor, tiazofurin (TR)β2βΞ²βDβribofuranosylthiazoleβ4βcarboxamide, which exhibited oncolytic activity in patients with chronic myelogenous leukaemia (CML) in blast crisis was found to inhibit the growth of human neuroblastoma SKβNβSH cells with an IC~50~ of 4.2
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