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Metabolism of the pyrrolizidine alkaloid metabolite trans-4-hydroxy-2-hexenal by mouse liver aldehyde dehydrogenases

✍ Scribed by Michael W. Lamé; H.J. Segall


Book ID
113206866
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
868 KB
Volume
82
Category
Article
ISSN
0041-008X

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✍ Griffin, Donna S. ;Segall, H. J. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 699 KB

The pyrrolizidine alkaloid senecionine has been shown to be hepatotoxic, genotoxic, and cytotoxic. However, the biochemical mechanism by which senecionine produces hepatocellular toxicity remains to be elucidated. The role of calcium homeostasis in toxic liver injury was examined in isolated rat hep