Metabolism of tetrachlorophenols in the rat

✍ Scribed by Ulf G. Ahlborg; Kerstin Larsson

• Book ID: 104736225
• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 571 KB
• Volume: 40
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00353280

✦ Synopsis

The' three isomers of tetrachlorophenol were administrated intraperi-toneaUy to rats and the urinary excretion products studied. Tetrachloro-p-hydroquinone was identified as a major metabolite of 2,3,5,6-tetrachlorophenol, constituing about 35% of the dose given. Trichloro-p-hydroquinone was identified as a minor metabolite of both 2,3,4,5-and 2,3,4,6-tetraehlorophenol. 2,3,5,6tetrachlorophenol was eliminated within 24 h, 2,3,4,6-tetrachlorophenol within 48 h while only 60% of the given dose of 2,3,4,5-tetrachiorophcnol could be recovered within 72 h.

The acute toxicity of the tetrachlorophenols and tetrachloro-p-hydroquinone was studied in mice upon oral and intraperitoneal administration. 2,3,5,6-tetrachlorophenol (LDs0 p.o. 109 mg 9 kg -1) was the most toxic compound followed by 2,3,4,6-and 2,3,4,5-tetrachlorophenol (LDs0 p.o. 131 and 400 mg 9 kg -1, respectively). Tetrachioro-p-hydroquinone proved to have low oral toxicity (LD~0 p.o. 500 mg 9 kg -~) but was more toxic than the tetrachiorophenols when administered intraperitoneally. The oral LDs0 for pentachlorophenol, under identical experimental conditions, was found to be 74 mg. kg-L