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Metabolism of sphingomyelin by intact cultured fibroblasts: Differentiation of Niemann-Pick disease types A and B

✍ Scribed by Arthur L. Beaudet; Aesta A. Manschreck


Book ID
117056062
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
356 KB
Volume
105
Category
Article
ISSN
0006-291X

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Sphingomyelin is an important lipid component of cell membranes and lipoproteins that can be hydrolyzed by sphingomyelinases into ceramide and phosphorylcholine. The Type A and B forms of Niemann-Pick disease (NPD) are lipid storage disorders due to the deficient activity of the enzyme acid sphingom