Metabolism of leukotrienes is impaired in hepatocytes from rats with thioacetamide-induced liver cirrhosis
✍ Scribed by R. Dargel
- Book ID
- 116163726
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 592 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0952-3278
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Uptake, metabolism and biliary elimination of infused cysteinyl leukotrienes were investigated in single-pass perfused rat liver. Hypoxia did not impair uptake of infused [3H]leukotriene C4, but inhibited biliary excretion of radioactivity by about 50% compared with normoxic control experiments. In
Thioacetamide-induced rat cirrhosis was characterized by single-cell necroses, fibrosis, nodular parenchyma, decrease in parenchymal volume density and an increase in liver weight per body weight so that the total amount of parenchyma was not altered. The glycogen content was normal, and signs of de